ABSTRACT
Two drugs have been authorized by the Algerian health Ministry to be used in Algeria to treat coronavirus disease 2019 (COVID-19) patients, once is Hydroxychloroquine (HCQ) and the other is Chloroquine (CQ). These drugs have been theoretically studied in order to know their active sites, and vibrational and electronic properties using Density Functional Theory (DFT) at the B3LYP/6-31G (d.p) level. The optimized molecular structures, the vibrational spectra, the HOMO and LUMO properties, dipole moments, Molecular Electrostatic Potentials (MEP), and atomic charges are calculated. In addition, the reactivity of drug molecules has been discussed by calculating some descriptors such as energy gap, hardness, local softness, electronegativity, and electrophilicity.
ABSTRACT
"Completing an entry is no small feat, even on the best of terms...This year's competition stands out in particular since the competing teams have had to overcome challenges and disruptions of a global pandemic in addition to making their blade," said Garry W. Warren, chair of the TMS Foundation Board of Trustees, as he commenced the 2022 TMS Bladesmithing Competition teams in opening the 2022 TMS Bladesmithing Competition Awards Ceremony. Held during the TMS 2022 Annual Meeting & Exhibition (TMS2022), 18 teams of university students rose to the challenge of forming a blade through hand hammering or trip hammer forging in the fourth iteration of the TMS Bladesmithing Competition in Anaheim CA. On display in the Exhibition Hall, TMS2022 attendees were delighted with this year's entries. The unique program provides the next generation of scientists and engineers with an opportunity to demonstrate their creativity, resourcefulness, artistic talents and determination as well as their knowledge of materials. Here, awardees in various categories are also highlighted.
ABSTRACT
In this work, colloidal silver has been added into an acrylic clear cataphoretic bath, evaluating the effect of two different filler amounts on the durability of the composite coatings. The three series of samples were characterized by electron microscopy to assess the possible change in morphology introduced by the silver-based additive. The protective properties of the coatings were evaluated by a salt spray chamber exposure and electrochemical impedance spectroscopy measurements, evidencing the negative effect provided by high amount of silver, which introduced discontinuities in the acrylic matrix. Finally, the durability of composite coatings was studied by exposing them to UV-B radiation, observing a strong phenomenon of silver degradation. Although the coating containing high concentrations of silver demonstrated poor durability, this study revealed that small amounts of silver can be used to provide particular aesthetic features, but also to improve the protective performance of cataphoretic coatings.
ABSTRACT
The versatile behavior of many Schiff bases is due to the presence of the azomethine group. In this work, we synthesized a novel polynuclear Schiff base [ANHIS] derived from anthrone and histidine, characterized using spectroscopic tools, and evaluated its anti-corrosion and anti-viral potencies. Conventional weight-loss method, electrochemical impedance spectroscopic investigation (EIS), potentiodynamic polarization studies (Tafel), adsorption studies, and quantum chemical calculations were used to investigate the anticorrosion behavior. The result showed that the Schiff base interacted with the surface metal atoms and provides good protection to the carbon steel surface against corrosion in an acid medium. A mixed-type inhibitor action of ANHIS was determined by Tafel plot analysis. A plausible mechanism of inhibition action is also anticipated. SEM analyses were carried out to explore the surface characteristics of the metal in the absence and presence of ANHIS. Drug likeness and ADMET properties of ANHIS were screened using online web servers. The preliminary IN SILICO pharmacokinetics and medicinal chemistry studies revealed that the molecule shows a very good drug-like property. The toxicity studies predict that it has less or no toxic behavior (carcinogenic in mice and non-carcinogenic in rats). The antiviral activity of the molecule was investigated on SARS-CoV-2(COVID-19 virus) using Autodock software. Docking studies showed that the polynuclear molecule ANHIS possessed hydrogen bonding, aromatic and hydrophobic interactions with the binding site of the main receptor of the COVID-19 virus. The docking score is comparable with the score value of anti-HIV drugs such as lopinavir and indinavir.
ABSTRACT
Dr. N was satisfied with patient screening and triage, the use of proper personal protective equipment, hand hygiene, chairside and surface asepsis, sharps safety, post-exposure management, respiratory hygiene and cough etiquette, and dental unit water safety. [...]Dr. N wanted to make sure that other less visible areas of infection prevention and control had not been accidentally slighted. Since the sterilization staff person was fairly new, the infection control coordinator (ICC) was charged with re-analyzing current practices for instrument reprocessing. The ICC reviewed the Centers for Disease Control and Prevention (CDC) guidelines and checklists, and used standard operating procedures to review current activity. On September 24, 2021 the CDC recommended booster doses: * people 65 years and older and residents in long-term care settings should receive a booster shot of Pfizer-BioNTech's COVID-19 vaccine at least 6 months after their Pfizer-BioNTech primary series, * people aged 50-64 years with underlying medical conditions should receive a booster shot of Pfizer-BioNTech's COVID-19 vaccine at least 6 months after their Pfizer-BioNTech primary series, * people aged 18-49 years with underlying medical conditions may receive a booster shot of Pfizer-BioNTech's COVID-19 vaccine at least 6 months after their Pfizer-BioNTech primary series, based on their individual benefits and risks, and * people aged 18-64 years who are at increased risk for COVID-19 exposure and transmission because of occupational or institutional setting may receive a booster shot of Pfizer-BioNTech's COVID-19 vaccine at least 6